Denagard Liquid Concentrate 1 Liter Swine Dysentary Pigs tiamulin

Description

Denagard Liquid Concentrate 1 Liter
. 12.5% Concentration is used to treat a variety of diseases in swine including swine dysentery. A very versatile water soluble antibiotic. Normal mixing rate for gut issues is 1liter per 512 gallons driking water, but please see below for specific mixing instructions. Thanks for looking and come back anytime.
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Denagard Liquid Concentrate 12.5%
Manufacturer: Novartis (Farm Animal)
(tiamulin)
12.5% Tiamulin hydrogen fumarate
NADA 140-916, Approved by FDA
Description
Denagard (tiamulin) Liquid Concentrate is a solution containing 12.5% tiamulin hydrogen fumarate (w/v) in an aqueous solution. The active ingredient, tiamulin, chemically is 14-desoxy-14-[(2-diethylaminoethyl) mercaptoacetoxy] mutilin hydrogen fumarate, a semi-synthetic diterpene antibiotic. Denagard Liquid Concentrate is for use only in preparing medicated drinking water for swine.
Actions:
Tiamulin is active against
Brachyspira
(formerly
Serpulina
or
Treponema)
hyodysenteriae
and
Actinobacillus pleuropneumoniae
. It is readily absorbed from the gut and can be found in the blood within 30 minutes after dosing.
Denagard Liquid Concentrate 12.5% Indications
Denagard (tiamulin), when administered in the drinking water for five consecutive days, is an effective antibiotic for the treatment of swine dysentery associated with
Brachyspira
(formerly
Serpulina
or
Treponema) hyodysenteriae
susceptible to tiamulin at a dose level of 3.5 mg tiamulin hydrogen fumarate per pound of body weight daily and for treatment of swine pneumonia due to
Actinobacillus pleuropneumoniae
susceptible to tiamulin when given at 10.5 mg tiamulin hydrogen fumarate per pound of body weight daily.
Contraindications
Swine being treated with Denagard (tiamulin) should not have access to feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin) as adverse reactions may occur.
Warning
Keep out of reach of children. Avoid contact with skin. Direct contact with skin or mucous membranes may cause irritation.
Withdraw medicated water 3 days before slaughter after treatment at 3.5 mg per pound and 7 days before slaughter following treatment at 10.5 mg per pound body weight.
Denagard Liquid Concentrate 12.5% Caution
For use in drinking water of swine only. Prepare fresh medicated water daily. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined. For animal use only – not for use in humans.
Adverse Reactions
Overdoses of Denagard have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. If signs of toxicity occur, discontinue use of medicated water and replace with clean, fresh water.
In rare cases, redness of the skin primarily over the ham and underline has been observed during medication. If these signs appear, discontinue use of this drug. Provide ample clean drinking water. Thoroughly rinse (hose down) the housing to remove urine and feces from animal contact surfaces or move the animals to clean pens. If the condition persists, consult your veterinarian.
Studies to evaluate the safety of the water soluble form of tiamulin in breeding swine have not been done.
Use Directions:
Do not use undiluted.
The concentration of tiamulin in the drinking water must be adjusted to compensate for variation in water consumption due to weight or size of the pig, environmental temperature and other factors. It is important that pigs receive the proper drug dose, 3.5 mg tiamulin hydrogen fumarate per pound for swine dysentery or 10.5 mg tiamulin hydrogen fumarate per pound for swine pneumonia, each day for 5 consecutive days.
Table 1
Approximate daily water consumption per pig.
Pig Weight, lb
Water Intake, gal.
20
0.3 – 0.5
45
0.4 – 1.1
75
0.7 – 1.5
125
1.0 – 2.0
180
1.2 – 3.0
Note:
1. Prepare fresh medicated drinking water every day for the 5 day treatment period.
2. Water medicated with Denagard should be the only source of drinking water during the treatment period.
Directions For Preparing Denagard Medicated Solutions
Determine the amount of Denagard Liquid Concentrate needed to medicate the desired volume of drinking water at the proper concentration. Carefully measure out this amount, add it to the water and stir to thoroughly mix.
Table 2 Denagard Liquid Concentrate
One Liter
Net tiamulin hydrogen fumarate content:
125,000 mg
Disease to be treated:
Swine Dysentery
Swine Pneumonia
Daily tiamulin hydrogen fumarate required per pound body weight:
3.5 mg
10.5 mg
Required treatment duration:
5 days
5 days
Pig body weight this bottle will treat for
ONE
day:
35,714 lb
11,905 lb
Number of pigs this bottle will treat for
ONE
day:
Pig Wt, lb
20
1,786
595
45
794
264
75
476
159
125
286
95
180
198
66
Suggested final dilution of:
1 bottle (1 Liter)
550 gal
–
3 bottles (3 Liters)
–
550 gal
1/4 bottle (0.25 Liters)
137 gal
46 gal
3/4 bottle (0.75 Liters)
–
137 gal
Tiamulin hydrogen fumarate concentration per gallon at suggested final dilution*
227 mg
(60 ppm)
681 mg
(180 ppm)
*Note:
Increase or decrease dilution rate as required to obtain proper daily drug dose.
Directions for using Denagard In medicated proportioners:
One liter of Denagard Liquid Concentrate mixed with water to make four gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 550 gallons of drinking water for treatment of swine dysentery. Three liters of Denagard Liquid Concentrate mixed with water to make four gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 681 mg tiamulin hydrogen fumarate per gallon to a total of 550 gallons of drinking water for treatment of swine pneumonia.
One-half liter (500 mL) of Denagard Liquid Concentrate mixed with water to make two gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 275 gallons of drinking water for treatment of swine dysentery. Use 1.5 liters (1,500 mL) of Denagard Liquid Concentrate in two gallons of stock solution to be metered at one fluid ounce per gallon to deliver 681 mg per gallon to a total of 275 gallons of drinking water for treatment of swine pneumonia.
One-quarter liter (250 mL) of Denagard Liquid Concentrate diluted with water to make one gallon of stock solution and this stock solution metered at one fluid ounce of drinking water with a medication proportioner will provide 227 mg of tiamulin hydrogen fumarate per gallon to 137 gallons of drinking water for treatment of swine dysentery.
Use 0.75 liters (750 mL) of Denagard Liquid Concentrate per gallon of stock solution to be metered at one fluid ounce per gallon to provide 681 mg per gallon to 137 gallons of drinking water for treatment of swine pneumonia.
In barrels or tanks:
One-tenth liter (100 mL) of Denagard Liquid Concentrate will medicate 51 gallons of drinking water at 227 mg per gallon for treatment of swine dysentery or 17 gallons at 681 mg per gallon for treatment of swine pneumonia.
Measure Denagard Liquid Concentrate carefully, pour into the proper amount of water and thoroughly mix. The concentration of tiamulin hydrogen fumarate in the stock solution and in the drinking water delivered must be adjusted to compensate for variation in water consumption by pigs due to body weight, environmental and other factors. It is important that the pigs receive the proper drug dose of 3.5 mg of tiamulin hydrogen fumarate per pound of body weight daily for 5 consecutive days for treatment of swine dysentery or a dose of 10.5 mg per pound body weight daily for 5 consecutive days for treatment of swine pneumonia.
Attention:
If no response to treatment is obtained within 5 days re-establish the diagnosis. Failure of response may be related to the presence of non-susceptible organisms of other complicating disease conditions. Because of the tendency for the disease to recur on premises with a history of swine dysentery or with swine pneumonia, a control program should be implemented after treatment. Drugs are not substitutes for proper sanitary measures or good management, but should be used in conjunction with such practices.
Container Size
Active Ingredients
Liter bottles (33.8 fl oz; 1000 mL)
12.5% (125.0 g) Tiamulin hydrogen fumarate